中国·hy590海洋之神检测中心(股份)有限公司-Baidu百科NO.1

博士，hy590海洋之神检测中心研究员，博士生导师/天然药物党支部书记，上海交通大学“SMC-晨星青年学者奖励计划”优秀青年教师。2007年10月毕业于沈阳药科大学，获得博士学位（导师：程卯生教授、李松院士）。长期从事中药/化学药品仿生（细胞膜、囊泡等）创新制剂研究与转化工作，以及药品监管政策研究。在Biomaterials、Journal of Controlled Release等本领域重要期刊累计发表第一或通讯作者（含共同）SCI英文文章30余篇，其中JCR一区15篇，ESI高被引论文1篇，授权专利17项。参编上海交通大学学生规划教材《现代药物研发实践》，主讲本科生“中药药剂学”、“药事管理”、研究生“药事法规理论与实务”课程。参讲本科生《药物研发实验》、研究生《药物代谢与药物动力学》。
工作经历:
2025.01.01-今 hy590海洋之神检测中心，研究员，博士生导师
2017.01-2024.12 hy590海洋之神检测中心，副教授，硕士生导师
2013.09-2016.12 hy590海洋之神检测中心，助理研究员，硕士生导师
2012.04-2013.03 美国加州大学圣迭戈分校纳米工程系，访问学者
（合作导师：张良方教授）
2008.02-2012.03 hy590海洋之神检测中心，助理研究员
学术兼职：
1、上海市药学会中药专委会委员
2、上海市营养学会特殊食品专委会委员

1、微米/纳米仿生给药系统构建与作用机制研究
2、中药创新制剂开发（临床前）与转化

近五年发表论文（通讯作者）：
1.Xiaoying Shi, Tianyi Shen, Muge Gu, Yuanye Guan, Gulizeba Aimaiti, Wei Yu, Xiangqi Zhang, Weien Yuan⁎, Jing Su⁎.Development of a novel Cu-Mn hydroxide layered nanosheet-loaded drug modulating the tumour microenvironment and enhancing antitumor effects[J]. J. Colloid Interface Sci., 2025, 696, 137904.
2.Hongyu Zhong, Yichen Li, Faisal Raza, Jiyuan Xie, Ruonan Rong, Mingfeng Qiu*, Jing Su*. RBCs as a bioinspired drug delivery system for co-delivery of irinotecan and nanoalumina enhances colorectal cancer Therapy[J]. Mol. Pharm.,2025, 22, 2521-2534.
3.Hang Xiao, Faisal Raza, Kunwei Li, Jinpu Song, Hajra Zafar, Shiqi Yang, Jing Su⁎, Mingfeng Qiu⁎. Cell membrane derived biomimetic nanomedicine for precision delivery of traditional Chinese medicine in cancer therapy[J]. J. Control. Release., 2025, 383, 113829.
4.刘宇浩，刀会仙，谢纪园，杨澜，杜若飞，邱明丰，苏靖*. 傣心舒颗粒成型工艺研究及其物理指纹图谱建立[J]. 中成药，2025, 47(1), 222-228.
5.Wenkai Zhang1, Yi Jin1, Jiayu Wang, Muge Gu, Yue Wang, Xiangqi Zhang, Yihui Zhang, Wei Yu, Yao Liu, Weien Yuan⁎, Jing Su⁎. Co-delivery of PROTAC and siRNA via novel liposomes for the treatment of malignant tumors[J]. J. Colloid Interface Sci., 2025, 678, 896-907.
6.Shiqi Yang1, Faisal Raza1, Kunwei Li, Yujiao Qiu, Jing Su*, Mingfeng Qiu*. Maximizing arsenic trioxide’s anticancer potential: Targeted nanocarriers for solid tumor therapy[J]. Colloids Surf. B Biointerfaces, 2024, 241, 114014.
7.Shiqi Yang, Bo Zheng, Faisal Raza, Shulei Zhang, Wei-en Yuan, Jing Su*, Mingfeng Qiu*. Tumor-derived microvesicles for cancer therapy[J]. Biomater. Sci., 2024, 12, 1131-1150.
8.Jiyuan Xie1, Ruonan Rong1, Hongyu Zhong, Lan Yang, Mingfeng Qiu*, Jing Su*. Gemcitabine hydrochloride drug-delivery system based on folic acid/gold nanoparticle co-modified red blood cells for breast cancer treatment[J]. ACS Appl. Nano Mater., 2024, 7, 10498-10510.
9.Yichen Li1, Enge Xu1, Ruonan Rong, Shulei Zhang, Weien Yuan, Mingfeng Qiu*, Jing Su*. Glutaraldehyde modified red blood cells delivering artesunate to the liver as a dual therapeutic and prophylactic antimalaria strategy[J]. J. Mater. Chem. B, 2023, 11, 7490-7501.
10. Ruonan Rong, Faisal Raza, Yuhao Liu, Weien Yuan, Jing Su*, Mingfeng Qiu*. Blood cell-based drug delivery systems: A biomimetic platform for antibacterial therapy[J]. Eur. J. Pharm. Biopharm., 2022, 177, 273-288.
11. Xuerui Wang, Mengyuan Zheng, Faisal Raza, Yuhao Liu, Yiqi Wei, Mingfeng Qiu*, Jing Su*. Recent developments in mesoporous silica nanoparticles for tumor theranostic applications[J]. Curr. Pharm. Des., 2022, 28(2), 151-164.
12. Faisal Raza，Siyu Liu, Hajra Zafa, Zul Kamal, Bo Zheng, Jing Su*, Mingfeng Qiu*. Recent advances in gelatin-based nanomedicine for targeted delivery of anti-cancer drugs[J]. Curr. Pharm. Des., 2022, 28(2), 380-394.
13.Yichen Li, Faisal Raza, Yuhao Liu, Yiqi Wei, Ruonan Rong, Mengyuan Zheng, Weien Yuan, Jing Su*, Mingfeng Qiu*. Clinical progress and advanced research of red blood cells based drug delivery system[J]. Biomaterials, 2021, 279, 121202.
14.Faisal Raza, Hajra Zafar, Shulei Zhang, Zul Kamal, Jing Su*, Weien Yuan*, Mingfeng Qiu*. Recent advances in cell membrane-derived biomimetic nanotechnology for cancer immunotherapy[J]. Adv. Healthc. Mater., 2021,10, 2002081.
15.Xinyi Wu, Yichen Li, Faisal Raza, Xuerui Wang, Shulei Zhang, Ruonan Rong, Mingfeng Qiu*, Jing Su*. Red blood cell membrane-camouflaged tedizolid phosphate-loaded PLGA nanoparticles for bacterial-infection therapy[J]. Pharmaceutics, 2021, 13, 99.
16.Yumei Lian, Xuerui Wang, Pengcheng Guo, Yichen Li, Faisal Raza, Jing Su*, Mingfeng Qiu*. Erythrocyte membrane coated arsenic trioxide loaded-sodium alginate nanoparticles for tumor therapy[J]. Pharmaceutics, 2020, 12(1), 21.
17.Zhongyao Cheng, Siyu Liu, Xinyi Wu, Faisal Raza, Yichen Li, Weien Yuan, Mingfeng Qiu*, Jing Su*. Autologous erythrocytes delivery of berberine hydrochloride with long-acting effect for hypolipidemia treatment [J]. Drug Deliv., 2020, 27(1), 283-291.
18.Enge Xu, Xinyi Wu, Xiumei Zhang, Kamal Zul, Faisal Raza, Jing Su*, Mingfeng Qiu*. Study on the protection of dextran on erythrocytes during drug loading[J]. Colloids Surf. B Biointerfaces, 2020,189, 110882.

通过创制系列新型递送系统，实现了对经典中药活性成分（砒霜、青蒿琥酯、盐酸小檗碱）的高效递送，显著降低了毒性，增强了疗效，并探索了其中的作用机制；利用相关技术与企业合作，对其临床前抗脑卒中1类新药与红细胞作用进行探究，利用专业技术推动了该药物药理机制的发现（ZL201811559344.0）；此外，还将新型给药体系扩展到其他西药品种（吉西他滨、倍他米松、特地唑安等）的剂型研究，为这些药物仿生新剂型的研究与开发积累了科学理论和实践经验。在Biomaterials、Journal of Controlled Release等本领域重要期刊累计发表第一或通讯作者（含共同）SCI英文文章30余篇，其中JCR一区15篇，ESI高被引论文1篇，授权专利17项。
以上成果得到（均为项目负责人）国家自然科学基金（82374149、81001416）、国家科技部重大专项（2018ZX09711003-008-002）、上海市科委生物科技支撑专项（21S21902200）、上海市自然科学基金（18ZR1419700）、上海交通大学医工交叉项目（YG2010MS11、YG2011MS21、YG2015QN14、YG2021QN57），以及上海交通大学“SMC-晨星青年学者奖励计划”优秀青年教师（B）类科研基金（AF1700016）等资助。