中国·hy590海洋之神检测中心(股份)有限公司-Baidu百科NO.1

张宝红 博士，副教授，博士生导师，上海交通大学细胞工程及抗体药物教育部工程研究中心副主任，从事生物技术药物和抗体药物的研发工作。2002年毕业于中国海洋大学海洋生命学院，获得博士学位。曾先后赴澳大利亚、德国和美国进修。副主编出版《现代药物研发实践》教材一部；曾荣获上海交通大学教学成果奖一等奖1项（排名第一）、二等奖1项（排名第二）；荣获2016年上海交通大学优秀教师三等奖、上海交通大学“三八红旗手”，2017年度上海交通大学“教书育人奖”（个人奖）提名奖，2017年度上海交通大学“十佳班主任”，荣获2018 年中国产学研合作创新成果优秀奖（排名第二）。

新型抗体药物研发，包括双特异性抗体、抗体偶联药物、双特异性抗体偶联药物；抗体靶向降解；抗体纳米粒；抗体体内表达递送等相关研究。

1. Yali Yue, Junjun Liu, Hang Ma, Zhidi Pan, Lei Wang, Jiawei Zhang, Shusheng Wang, Yueqing Xie, Hua Jiang, Yanlin Bian, Mingyuan Wu, Yunsheng Yuan, Baohong Zhang*, Xiaodong Xiao*, Jianwei Zhu*. Generating potent and persistent antitumor immunity via affinity-tuned CAR-T cells targeting mesothelin. Acta Pharmacol Sin. 2025. https://doi.org/10.1038/s41401-025-01572-0.
2. Zixian Yu#, Yiren Cao#, Lei Wang#, Youli Tian, Rui Zou, Keer Chen, Weiwen Liu, Qiang Zhang, Qingjiang Wang, Baohong Zhang*, Chengxi Cao*. A Facile Method for Gel Electrophoresis with Intrinsic Fluorescence Imaging for Self-Aggregation and Stability Assay of Monoclonal Antibody. Anal Chem. 2025 Mar 21. 97 (13), 7388-7399.
3. Qunye He, Lei Wang, Lulu Huang, Yong Ke, Pameila Paerhati, Jiawei Zhang, Huifang Zong, Baohong Zhang*, Jianwei Zhu. A Plug-and-Play Ferritac Platform Degrading Membrane Proteins via Receptor Crosslinking. Adv Funct Mater. 2025, 2420004.
4. Yunji Liao# , Hang Ma#, Zhenyu Wang# , Shusheng Wang#, Yang He, Yunsong Chang, Huifang Zong, Haoneng Tang, Lei Wang, Yong Ke, Huiyu Cai, Ping Li, Jian Tang, Hua Chen, Aleksandra Drelich, Bi-Hung Peng, Jason Hsu, Vivian Tat, Chien-Te K Tseng, Jingjing Song, Yunsheng Yuan, Mingyuan Wu, Junjun Liu, Yali Yue, Xiaoju Zhang, Ziqi Wang, Li Yang, Jing Li, Xiaodan Ni, Hongshi Li , Yuning Xiang, Yanlin Bian, Baohong Zhang, Haiyang Yin, Dimiter S Dimitrov, John Gilly, Lei Han*, Hua Jiang*, Yueqing Xie*, Jianwei Zhu*. Rapid restoration of potent neutralization activity against the latest Omicron variant JN.1 via AI rational design and antibody engineering. Proc Natl Acad Sci USA. 2025;122(6): e2406659122.
5. Lei Wang, Yong Ke, Qunye He, Pameila Paerhati, Weiliang Zhuang, Yali Yue, Junjun Liu, Jiawei Zhang, Lulu Huang, Qiang Yin, Huifang Zong, Jianwei Zhu*, Baohong Zhang*. A novel ROR1-targeting antibody-PROTAC conjugate promotes BRD4 degradation for solid tumor treatment. Theranostics 2025; 15(4): 1238-1254.
6. En Zhang, Yong Ke, Weihong Ran, Yu Zhang, Ruihang Li, Xinkui Fang, Lei Wang, Baohong Zhang*, Tao Sun*. Assessment of Single-Cycle M-Protein Mutated Vesicular Stomatitis Virus as a Safe and Immunogenic Mucosal Vaccine Platform for SARS-CoV-2 Immunogen Delivery. Adv. Sci. 2024 Nov 11, 47: 2404197.
7. Yijia Min†, Yu Chen†, Lei Wang, Yong Ke, Fan Rong, Qunye He, Pameila Paerhati, Huifang Zong, Jianwei Zhu*, Yin Wang*, Baohong Zhang*. Supramolecular antibody-drug conjugates for combined antibody therapy and photothermal therapy targeting HER2-positive cancers. Int J Biol Macromol. 2024; 278:134622.
8. Junjun Liu#, Zhidi Pan#, Yali Yue, Shusheng Wang, Jie Chen, Hua Jiang, Baohong Zhang, Mingyuan Wu, Yunsheng Yuan, Yanlin Bian, Haiyang Yin, Lei Wang, Junyan Li, John Gilly, Yueqing Xie*, Jianwei Zhu*. T cell-redirecting antibody for treatment of solid tumors via targeting mesothelin. Acta Pharmacol Sin. 2024;45: 2186-2198.
9. Jiawei Zhang, Junjun Liu, Yali Yue, Lei Wang, Qunye He, Shuyi Xu, Junyan Li, Yunji Liao, Yu Chen, Shusheng Wang, Yueqing Xie, Baohong Zhang, Yanlin Bian, Dimiter S Dimitrov, Yunsheng Yuan*, Jianwei Zhu*. The immunotoxin targeting PRLR increases tamoxifen sensitivity and enhances the efficacy of chemotherapy in breast cancer. J Exp Clin Cancer Res. 2024;43(1):173.
10. Huifang Zong, Xi Li, Lei Han, Lei Wang, Junjun Liu, Yali Yue, Jie Chen, Yong Ke, Hua Jiang, Yueqing Xie , Baohong Zhang*, Jianwei Zhu*. A novel bispecific antibody drug conjugate targeting HER2 and HER3 with potent therapeutic efficacy against breast cancer. Acta Pharmacol Sin. 2024;45(8):1727-1739.
11. Yuan Yuan, Junyan Li, Jie Chen, Lei Han, Lei Wang, Yali Yue, Junjun Liu, Baohong Zhang, Yunsheng Yuan, Mingyuan Wu, Yanlin Bian, Yueqing Xie, Jianwei Zhu. Characterization of a novel T cell-engaging bispecific antibody for elimination of L1CAM-positive tumors. Biomed Pharmacother. 2024:174:116565.
12. Jingyi Bai†, Xi Li†, Jun Zhao, Huifang Zong, Yuan Yuan, Lei Wang, Xiaoshuai Zhang, Yong Ke, Lei Han, Jianrong Xu, Buyong Ma*, Baohong Zhang*, Jianwei Zhu. Re-Engineering Therapeutic Anti-Aβ Monoclonal Antibody to Target Amyloid Light Chain. Int. J. Mol. Sci. 2024;25(3):1593.
13. Yeneng Dai, Lipeng Zhu, Xue Li, Fengjuan Zhang, Kai Chen, Guanda Jiao, Yu Liu, Ziyi Yang, Ziang Guo, Baohong Zhang*, Qingming Shen*, Qi Zhao*. A biomimetic cuproptosis amplifier for targeted NIR-II fluorescence/ photoacoustic imaging-guided synergistic NIR-II photothermal immunotherapy. Biomaterials. 2024, 305:122455.
14. Weiliang Zhuang, Wei Zhang, Liping Xie, Lei Wang, Yuan Li, Ziyu Wang, Ao Zhang, Haitao Qiu, Jun Feng, Baohong Zhang* and Youjia Hu*. Generation and Characterization of SORT1-Targeted Antibody–Drug Conjugate for the Treatment of SORT1-Positive Breast Tumor. Int. J. Mol. Sci. 2023, 24, 17631.
15. Yong Ke†, En Zhang†, Jianming Guo, Xiaoxiao Zhang, Lei Wang, Duo Chen, Xinkui Fang, Jianwei Zhu, Feng Li*, Tao Sun*, Baohong Zhang*. Immunogenicity of mucosal COVID-19 vaccine candidates based on the highly attenuated vesicular stomatitis virus vector (VSVMT) in golden syrian hamster. Acta Pharmaceutica Sinica B. 2023; 13(12): 4856-4874.
16. Xiaoshuai Zhang, Haiyan Guo, Jie Chen, Chenxiao Xu, Lei Wang, Yong Ke, Yang Gao, Baohong Zhang*, Jianwei Zhu. Highly proliferative and hypodifferentiated CAR-T cells targeting B7–H3 enhance antitumor activity against ovarian and triple-negative breast cancers. Cancer Letters. 2023; 572:216355.
17. Weiliang Zhuang, Wei Zhang, Lei Wang, Liping Xie, Jun Feng, Baohong Zhang* and Youjia Hu*. Generation of a Novel SORT1×HER2 Bispecific Antibody–Drug Conjugate Targeting HER2-Low-Expression Tumor. Int. J. Mol. Sci. 2023, 24, 16056.
18. Jie Chen, Zhidi Pan, Lei Han, Junjun Liu, Yali Yue, Xiaodong Xiao, Baohong Zhang, Mingyuan Wu, Yunsheng Yuan, Yanlin Bian, Hua Jiang, Yueqing Xie, Jianwei Zhu*. Binding domain on CD22 molecules contributing to the biological activity of T cell-engaging bispecific antibodies. Heliyon. 2023, 9(7):e17960.
19. Hang Ma, Huifang Zong, Junjun Liu, Yali Yue, Yong Ke, Yunji Liao, Haoneng Tang, Lei Wang, Shusheng Wang, Yunsheng Yuan, Mingyuan Wu, Yanlin Bian, Baohong Zhang, Haiyang Yin, Hua Jiang, Tao Sun, Lei Han*, Yueqing Xie*, Jianwei Zhu*. Long-term passaging of pseudo-typed SARS-CoV-2 reveals the breadth of monoclonal and bispecific antibody cocktails. Acta Pharmacol Sin. 2023, 44(7): 1455-1463.
20. Haoneng Tang†, Yong Ke†, Yunji Liao†, Yanlin Bian, Yunsheng Yuan, Ziqi Wang, Li Yang, Hang Ma, Tao Sun, Baohong Zhang*, Xiaoju Zhang*, Mingyuan Wu*, Jianwei Zhu*. Mutational escape prevention by combination of four neutralizing antibodies that target RBD conserved regions and stem helix. Virologica Sinica. 2022;37(6):860-873.
21. Yanchao Wang, Chen Zheng, Chao Zhuang, Qiang Fu, Baohong Zhang, Yanling Bian, Nianmin Qi*, Jianwei Zhu*. Characterization and pre-clinical assessment of a proposed biosimilar to its originator Omalizumab. Eur J Pharm Sci. 2022;178:106292.
22. Lei Wang†, Yu Qiao†, Huifang Zong, Lei Han, Yong Ke, Zhidi Pan, Jie Chen, Jun Lu, Jinyao Li, Tianlei Ying, Baohong Zhang*, Jianwei Zhu. IgG-like Bispecific Antibody CD3EpCAM Generated by Split Intein against Colorectal Cancer. Frontiers in Pharmacology. 2022, 13: 803059.
23. Ma H, Guo Y, Tang H, Tseng CK, Wang L, Zong H, Wang Z, He Y, Chang Y, Wang S, Huang H, Ke Y, Yuan Y, Wu M, Zhang Y, Drelich A, Kempaiah KR, Peng BH, Wang A, Yang K, Yin H, Liu J, Yue Y, Xu W, Zhu S, Ji T, Zhang X, Wang Z, Li G, Liu G, Song J, Mu L, Xiang Z, Song Z, Chen H, Bian Y, Zhang B, Chen H, Zhang J, Liao Y, Zhang L, Yang L, Chen Y, Gilly J, Xiao X, Han L, Jiang H, Xie Y, Zhou Q, Zhu J. Broad ultra-potent neutralization of SARS-CoV-2 variants by monoclonal antibodies specific to thetip of RBD. Cell Discov. 2022, 8(1):16.
24. Yijie Li, Mingyang Zhang, Haijie Han, Baohong Zhang, John B. Matson, Defu Chen, Wei Li, Yin Wang*. Peptide-based supramolecular photodynamic therapy systems: From rational molecular design to effective cancer treatment. Chemical Engineering Journal. 2022, 436:135240.
25. Huifang Zong, Lei Han, Jie Chen, Zhidi Pan, Lei Wang, Rui Sun, Kai Ding, Yueqing Xie, Hua Jiang, Huili Lu, John Gilly, Baohong Zhang*, Jianwei Zhu*. Kinetics study of the natural split Npu DnaE intein in the generation of bispecifc IgG antibodies. Applied Microbiology and Biotechnology. 2022, 106:161-171.
26. Zhidi Pan, Jie Chen, Xiaodong Xiao, Yueqing Xie, Hua Jiang, Baohong Zhang, Huili Lu, Yunsheng Yuan, Lei Han, Yuexian Zhou, Huifang Zong, Lei Wang, Rui Sun, Jianwei Zhu*. Characterization of a novel bispecific antibody targeting tissue factor-positive tumors with T cell engagement. Acta Pharmaceutica Sinica B. 2022, 12(4):1928-1942.

先后主持参与各级课题20余项，在Acta Pharmaceutica Sinica B，Advanced Functional Materials，Cancer Letters，Advanced Science，Biomaterials，Theranotics等期刊发表SCI论文50余篇，申请专利20余项，其中国际专利5项。荣获2018 年中国产学研合作创新成果优秀奖（排名第二）。