Scientific Research
Tuo Jin
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Overview
Tuo Jin, Ph.D., D.Sc., Pharmaceutical Sciences/Physical Chemistry
Professor and Co-director, Center for BioDelivery Studeis
B.S. Nankai University China; D.Sc. Hokkaido University, Japan; Ph.D., University of Toronto
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Members
Fei Wu, B.S., M.Sc., Shenyang Pharmaceutical University;
Ph.D., Shanghai Jiao Tong University
Weien Yuan, B.S., M.Sc., Guangxi Normal University
Ph.D., Shanghai Jiao Tong University
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Research Field
Research Interests:
Developing druggable delivery systems and advanced dosage forms of biologic medicines
Recent inventions:
- Sustained-release microspheres of delicate protein drugs in native form and highly simplified production engineering;
- Phase-transition microneedle patches for efficient transdermal delivery of proteins;
- Nano-encapsulation of delicate proteins in native form;
- Uni-molecular polyplexes formed form from a networked cationic polymer of customizable size and pH-responsive degradability;
- Functionalization of polyplexes with a self-assembled unilamella membrane of rationally designed a tri-block copolymer for systemic delivery of nucleic acids.
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Publications & Patents
1. Tuo Jin*, Jiahao Zhu, Fei Wu, Weien Yuan, Lee L. Geng, Hua Zhu; Preparing polymer-based sustained-release systems without exposing proteins to water–oil or water–air interfaces and cross-linking reagents,
J. Control. Release, 2008,128,50–59
2. Yan Geng, Weien Yuan, Fei Wu, Jingle Chen, Mu He, Tuo Jin*; Formulating erythropoietin-loaded sustained-release PLGA microspheres without protein aggregation
J. Control. Release, 2008, 130(3), 259-265
3. Sixing Yang, Fei Wu, Jianguo Liu, Guorong Fan, William Welse, Hua Zhu, Tuo Jin*; Phase-transition microneedle patches for efficient and accurate transdermal delivery of insulin;
Adv. Func. Mater., 2015, 25/29, 4633-4641
4. Yulong Zhang, Fei Wu, Weien Yuan, Tuo Jin*; Polymersomes of asymmetric bilaer formed by phase-guided assembly;
J. Control. Release, 2010, 147(3): 413-419
5. Siyue Duan, Weien Yuan, Fei Wu, Tuo Jin*; Polyspermine imidazole-4,5-imine, a chemically dynamic and biologically responsive carrier system for intracellular delivery of siRNA;
Angew. Chem., 2012, 51/32 7038-7941
6. Xuemei Ge, Shiyue Dun, Fei Wu, Hua Zhu, Tuo Jin*; Polywraplex, functionalized polyplex by post-polyplexing assembly of a rationally designed tri-block copolymer membrane;
Adv. Func. Mater., 2015, 25/27, 3452-4363
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contact information
School of Pharmacy, Shanghai Jiao Tong University
800 Dongchuan Road, Shanghai, 200240
Office phone: +86-21-3420-4695
Lab. Phone: +86-21-3420-5072
Fax: +86-21-3420-5072
Tuo Jin, tjin@sjtu.edu,cn
Fei Wu, feiwu@sjtu.edu.cn
Weien Yuan, yuanweien@sjtu.edu.cn
